Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer.

ABSTRACT:

Abtract

Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the normal development of several endoderm-derived organs, including the prostate gland^1,2. FOXA1 is frequently mutated in hormone-receptor-driven prostate, breast, bladder and salivary-gland tumours^3-8. However, it is unclear how FOXA1 alterations affect the development of cancer, and FOXA1 has previously been ascribed both tumour-suppressive^9-11 and oncogenic^12-14 roles. Here we assemble an aggregate cohort of 1,546 prostate cancers and show that FOXA1 alterations fall into three structural classes that diverge in clinical incidence and genetic co-alteration profiles, with a collective prevalence of 35%. Class-1 activating mutations originate in earl

SUBMITTER: Parolia A 

PROVIDER: S-EPMC6661908 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature