Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC.

ABSTRACT:

Background

Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will affect greatly the drug discovery process.

Results

A series of N-benzenesulfonamide-1H-pyrazoles, oximes and hydrazones as celecoxib analogues was investigated with regard to their retention behavior using reversed-phase high performance liquid chromatography (RP-HPLC). The mobile phases employed for this study consist of a mixture of water and methanol in different proportions. In addition, the stationary phase utilized for this separation was C₁₈ silanized silica gel and using 200 nm as a detection wavelength. The retention behavior of the investigated compounds was determined based

SUBMITTER: Elmansi H 

PROVIDER: S-EPMC6661952 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature