CASMAP: detection of statistically significant combinations of SNPs in association mapping.

ABSTRACT:

Summary

Combinatorial association mapping aims to assess the statistical association of higher-order interactions of genetic markers with a phenotype of interest. This article presents combinatorial association mapping (CASMAP), a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Most importantly, unlike other existing significant pattern mining-based tools, CASMAP allows for the correction of categorical covariates such as age or gender, making it suitable for genome-wide association studies.

Availability and

SUBMITTER: Llinares-Lopez F 

PROVIDER: S-EPMC6662083 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature