Glycolate from microalgae: an efficient carbon source for biotechnological applications.

ABSTRACT: Glycolate is produced in autotrophic cells under high temperatures and C_i -limitation via oxygenation of ribulose-1,5-bisphosphate. In unicellular algae, glycolate is lost via excretion or metabolized via the C₂ cycle by consuming reductants, ATP and CO₂ emission (photorespiration). Therefore, photorespiration is an inhibitory process for biomass production. However, cells can be manipulated in a way that they become glycolate-producing 'cell factories', when the ratio carboxylation/oxygenation is 2. If under these conditions the C₂ cycle is blocked, glycolate excretion becomes the only pathway of photosynthetic carbon flow. The study aims to proof the biotechnological applicability of algal-based glycolate excretion as a new biotechnological pla

SUBMITTER: Taubert A 

PROVIDER: S-EPMC6662103 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature