Windkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study.

ABSTRACT: Background Waveform parameters derived from pressure-only Windkessel models are related to cardiovascular disease risk and could be useful for understanding arterial system function. However, prior reports varied in their adjustment for potential confounders. Methods and Results Carotid tonometry waveform data from 2539 participants (mean age 63±11 years, 58% women) of the Framingham Heart Study were used to derive Windkessel measures using pressure and assuming a linear model with fixed diastolic time constant (τ_dias) and variable asymptotic pressure (P_inf, median 54.5; 25th, 75th percentiles: 38.4, 64.9 mm Hg) or nonlinear model with inverse pressure-dependent τ_dias and fixed P_inf (20 mm Hg). During follow-up (median 15.1 years), 459 (18%) part

SUBMITTER: Behnam V 

PROVIDER: S-EPMC6662135 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature