Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice.

ABSTRACT: Background Exposure to fine airborne particulate matter ( PM _2.5) induces quantitative and qualitative defects in bone marrow-derived endothelial progenitor cells of mice, and similar outcomes in humans may contribute to vascular dysfunction and the cardiovascular morbidity and mortality associated with PM _2.5 exposure. Nevertheless, mechanisms underlying the pervasive effects of PM _2.5 are unclear and effective interventional strategies to mitigate against PM _2.5 toxicity are lacking. Furthermore, whether PM _2.5 exposure affects other types of bone marrow stem cells leading to additional hematological or immunological dysfunction is not clear. Methods and Results Mice given normal drinking water or that supplemented with carnosine, a

SUBMITTER: Abplanalp W 

PROVIDER: S-EPMC6662354 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature