Quantitative Systems Pharmacology Model of Chimeric Antigen Receptor T-Cell Therapy.

ABSTRACT: Chimeric antigen receptor T-cell (CART) therapy is a new and promising cancer therapy. However, severe toxicity due to cytokine release syndrome (CRS) in CART-treated patients highlighted the possible danger of this new therapy. Disease burden and CART doses are the potential factors associated with CRS but the detail relationships between these factors and the severity of the CRS remain largely unknown. In this study, the quantitative systems pharmacology (QSP) approach is used to quantify the complex relationships among CART doses, disease burden, and pro inflammatory cytokines in human subjects and to gain relevant insights into the determinant of clinical toxicity/efficacy in development of CART therapy. The expansion of CART and elimination of B cells are more highly correlated with d

SUBMITTER: Hardiansyah D 

PROVIDER: S-EPMC6662387 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature