Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer.

ABSTRACT:

Background

Metallothioneins (MTs) family comprises many isoforms, most of which are frequently dysregulated in a wide range of cancers. However, the expression pattern and exact role of each distinct MT family isoform which contributes to tumorigenesis, progression, and drug resistance of gastric cancer (GC) are still unclear.

Methods

Publicly available databases including Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, SurvExpress, MethHC, cBioportal, and GeneMANIA were accessed to perform an integrated bioinformatic analysis and try to detect fundamental relationships between each MT family member and GC.

Results

Bioinformatic data indicated that the mRNA expression of all MT family members was almost lowly expressed in GC com

SUBMITTER: Tong M 

PROVIDER: S-EPMC6662468 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature