Response rate profiles for major depressive disorder: Characterizing early response and longitudinal nonresponse.

ABSTRACT:

Background

Definition of response is critical when seeking to establish valid predictors of treatment success. However, response at the end of study or endpoint only provides one view of the overall clinical picture that is relevant in testing for predictors. The current study employed a classification technique designed to group subjects based on their rate of change over time, while simultaneously addressing the issue of controlling for baseline severity.

Methods

A set of latent class trajectory analyses, incorporating baseline level of symptoms, were performed on a sample of 344 depressed patients from a clinical trial evaluating the efficacy of cognitive behavior therapy and two antidepressant medications (escitalopram and duloxetine) in patients with major depressive di

SUBMITTER: Kelley ME 

PROVIDER: S-EPMC6662579 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature