Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.

ABSTRACT:

Introduction

Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential.

Methods

We compared the pathologic findings from a prospective autopsy cohort (n = 100) to Pittsburgh compound B PET (PiB-PET), ¹⁸F-fluorodeoxyglucose PET (FDG-PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed.

Results

PiB-PET showed strong correlations with Thal amyloid phase and Consortium to Establish a Registry for Alzheimer's Disease score and categorized 44% of Thal phase 1 participants as positive. FDG-PET and MRI correlated modestly with Braak tangle stage in Alzheimer's type pathology. A subset of participants with "none" or "sparse"

SUBMITTER: Lowe VJ 

PROVIDER: S-EPMC6662599 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature