Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival.

ABSTRACT: The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally measured proliferation and migration phenotypes across more than 40 breast cancer cell-lines. Based on the latter, we built and validated individual predictors of breast cancer proliferation and migration levels from the cells' transcriptomics. We then apply these predictors to estimate the proliferation and migration levels of more than 1000 TCGA breast cancer tumors. Reassuringly, both estimates increase with tumor's aggressiveness, as qualified by its stage, grade, and subtyp

SUBMITTER: Nair NU 

PROVIDER: S-EPMC6662662 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature