Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling.

ABSTRACT: Objective- Flow patterns differentially regulate endothelial cell phenotype, with laminar flow promoting vasodilation and disturbed flow promoting endothelial proinflammatory activation. CSE (cystathionine γ-lyase), a major source of hydrogen sulfide (H₂S) in endothelial cells, critically regulates cardiovascular function, by both promoting vasodilation and reducing endothelial activation. Therefore, we sought to investigate the role of CSE in the endothelial response to flow. Approach and Results- Wild-type C57Bl/6J and CSE knockout ( CSE^-/-) mice underwent partial carotid ligation to induce disturbed flow in the left carotid. In addition, endothelial cells isolated from wild-type and CSE ^-/- mice were exposed to either laminar or oscillatory flow, an in v

SUBMITTER: Yuan S 

PROVIDER: S-EPMC6662734 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature