Altered transcriptional regulatory proteins in glioblastoma and YBX1 as a potential regulator of tumor invasion.

ABSTRACT: We have studied differentially regulated nuclear proteome of the clinical tissue specimens of glioblastoma (GBM, WHO Grade IV) and lower grades of gliomas (Grade II and III) using high resolution mass spectrometry- based quantitative proteomics approach. The results showed altered expression of many regulatory proteins from the nucleus such as DNA binding proteins, transcription and post transcriptional processing factors and also included enrichment of nuclear proteins that are targets of granzyme signaling - an immune surveillance pathway. Protein - protein interaction network analysis using integrated proteomics and transcriptomics data of transcription factors and proteins for cell invasion process (drawn from another GBM dataset) revealed YBX1, a ubiquitous RNA and DNA-binding protein

SUBMITTER: Gupta MK 

PROVIDER: S-EPMC6662741 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature