Protein phosphatases regulate growth, development, cellulases and secondary metabolism in Trichoderma reesei.

ABSTRACT: Trichoderma reesei represents one of the most prolific producers of plant cell wall degrading enzymes. Recent research showed broad regulation by phosphorylation in T. reesei, including important transcription factors involved in cellulase regulation. To evaluate factors crucial for changes in these phosphorylation events, we studied non-essential protein phosphatases (PPs) of T. reesei. Viable deletion strains were tested for growth on different carbon sources, osmotic and oxidative stress response, asexual and sexual development, cellulase and protease production as well as secondary metabolism. Six PPs were found to be positive or negative regulators for cellulase production. A correlation of the effects of PPs on protease activities and cellulase activities was not detected. Hierarchic

SUBMITTER: Rodriguez-Iglesias A 

PROVIDER: S-EPMC6662751 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature