Prognostic and predictive role of tumour-associated macrophages in HER2 positive breast cancer.

ABSTRACT: Disease outcomes of HER2+ breast cancers have dramatically improved after targeted therapies, such as trastuzumab became available. The main mechanism of action of trastuzumab depends on immunoactivation, while immunosuppressive tumour phenotype has been linked to adverse outcomes. Current study included metastatic HER2+ breast cancer patients treated with trastuzumab (n = 40). Immunohistochemistry was conducted to detect nitric oxide synthase 2 (iNOS) expressing M1 polarized and CD163⁺ M2 polarized macrophages, FoxP3⁺ regulatory T-cells (Tregs), CD47 and indoleamine 2,3-dioxygenase 1 (IDO1). High number of iNOS⁺ M1-like macrophages, both in the center of the tumour (CT) and invasive margin (IM), was significantly associated with improved survival (p = 0.00

SUBMITTER: Honkanen TJ 

PROVIDER: S-EPMC6662906 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature