The circadian clock gene Bmal1 is required to control the timing of retinal neurogenesis and lamination of Muller glia in the mouse retina.

ABSTRACT: A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Here we show that the protein encoded by the circadian clock gene brain and muscle arnt-like protein-1 (Bmal1) is expressed in the embryonic retina and is required to regulate the timing of cell cycle exit. Accordingly, loss of Bmal1 during retinal neurogenesis results in increased S-phase entry and delayed cell cycle exit. Disr

SUBMITTER: Sawant OB 

PROVIDER: S-EPMC6662963 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature