Expression of integrins to control migration direction of electrotaxis.

ABSTRACT: Proper control of cell migration is critically important in many biologic processes, such as wound healing, immune surveillance, and development. Much progress has been made in the initiation of cell migration; however, little is known about termination and sometimes directional reversal. During active cell migration, as in wound healing, development, and immune surveillance, the integrin expression profile undergoes drastic changes. Here, we uncovered the extensive regulatory and even opposing roles of integrins in directional cell migration in electric fields (EFs), a potentially important endogenous guidance mechanism. We established cell lines that stably express specific integrins and determined their responses to applied EFs with a high throughput screen. Expression of specific integ

SUBMITTER: Zhu K 

PROVIDER: S-EPMC6662972 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature