Circulating CASK is associated with recurrent focal segmental glomerulosclerosis after transplantation.

ABSTRACT:

Introduction

Focal and Segmental GlomeruloSclerosis (FSGS) can cause nephrotic syndrome with a risk of progression to end-stage renal disease. The idiopathic form has a high rate of recurrence after transplantation, suggesting the presence of a systemic circulating factor that causes glomerular permeability and can be removed by plasmapheresis or protein-A immunoadsorption.

Results

To identify this circulating factor, the eluate proteins bound on therapeutic immunoadsorption with protein-A columns were analyzed by comparative electrophoresis and mass spectrometry. A soluble form of calcium/calmodulin-dependent serine protein kinase (CASK) was identified. CASK was immunoprecipitated only in the sera of patients with recurrent FSGS after transplantation and not in control pati

SUBMITTER: Beaudreuil S 

PROVIDER: S-EPMC6663006 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature