Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach.

ABSTRACT:

Background

The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios.

Methodology/principal findings

Age, height and weight data were collected from >26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was treated as the "gold standard" for this study. Following WHO recommended age-based dosing

SUBMITTER: Goss CW 

PROVIDER: S-EPMC6663033 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature