A Phosphinate-Containing Fluorophore Capable of Selectively Inducing Apoptosis in Cancer Cells.

ABSTRACT: Chemotherapeutic agents generally suffer from off-target cytotoxicity in noncancerous cell types, leading to undesired side effects. As a result, significant effort has been put into identifying compounds that are selective for cancerous over noncancerous cell types. Our laboratory has recently developed a series of near-infrared (NIR) fluorophores containing a phosphinate functionality at the bridging position of a xanthene scaffold, termed Nebraska Red (NR) fluorophores. Herein, we report the selective cytotoxicity of one NR derivative, NR₇₄₄ , against HeLa (cervical cancer) cells versus NIH-3T3 (noncancerous fibroblast) cells. Mechanistic studies based on the NIR fluorescence signal of NR₇₄₄ showed distinct subcellular localization in HeLa (mitochondrial) versus NI

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6663559 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature