HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy.

ABSTRACT:

Background

Prompt initiation of antiretroviral therapy (ART) for HIV-infected infants is strongly recommended but diagnostic confirmation is important as committing children to life-long ART carries serious health and social implications.

Methods

Two HIV-exposed infants in Johannesburg, South Africa were identified presenting with unusual trajectories of diagnostic nucleic acid amplification tests (NAAT) and viral load results.

Results

Case 1 had repeat indeterminate NAAT results during the first 3 weeks of life; repeat testing thereafter was negative with undetectable viral load including after daily nevirapine prophylaxis ended. ART was not initiated at this time. Case 2 had a single positive NAAT result at 1 month of age that prompted initiation of ART. Subsequent

SUBMITTER: Strehlau R 

PROVIDER: S-EPMC6663570 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature