Exercise ameliorates deficits in neural microstructure in a Disc1 model of psychiatric illness.

ABSTRACT: Recent studies have investigated the effectiveness of aerobic exercise to improve physical and mental health outcomes in schizophrenia; however, few have explicitly explored the impact of aerobic exercise on neural microstructure, which is hypothesized to mediate the behavioral changes observed. Neural microstructure is influenced by numerous genetic factors including DISC1, which is a major molecular scaffold protein that interacts with partners like GSK3β, NDEL1, and PDE4. DISC1 has been shown to play a role in neurogenesis, neuronal migration, neuronal maturation, and synaptic signaling. As with other genetic variants that present an increased risk for disease, mutations of the DISC1 gene have been implicated in the molecular intersection of schizophrenia and numerous other major psychi

SUBMITTER: Barnett BR 

PROVIDER: S-EPMC6663582 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature