A topical heparinoid-containing product improves epidermal permeability barrier homeostasis in mice.

ABSTRACT: Because of the importance of epidermal functions, including stratum corneum hydration and maintenance of permeability barrier homeostasis, in the pathogenesis of a variety of cutaneous and systemic disorders, a wide range of products has been developed to improve epidermal functions. However, the underlying mechanisms whereby certain products, including heparinoid-containing product, are far little understood. In the present study, we assessed the impact of a heparinoid-containing product, Hirudoid^® cream, on epidermal permeability barrier function and expression levels of a panel of epidermal mRNA related to the formation/maintenance of the permeability barrier in mouse skin. Our results showed that while the baseline levels of transepidermal water rates remained unchanged, tre

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6663615 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature