Myositis Autoantigen Expression Correlates With Muscle Regeneration but Not Autoantibody Specificity.

ABSTRACT:

Objective

Although more than a dozen myositis-specific autoantibodies (MSAs) have been identified, most patients with myositis are positive for a single MSA. The specific overexpression of a given myositis autoantigen in myositis muscle has been proposed as initiating and/or propagating autoimmunity against that particular autoantigen. The present study was undertaken to test this hypothesis.

Methods

In order to quantify autoantigen RNA expression, RNA sequencing was performed on muscle biopsy samples from control subjects, MSA-positive patients with myositis, regenerating mouse muscles, and cultured human muscle cells.

Results

Muscle biopsy samples were available from 20 control subjects and 106 patients with autoantibodies recognizing hydroxymethylglutaryl-coenzyme

SUBMITTER: Pinal-Fernandez I 

PROVIDER: S-EPMC6663619 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature