Body mass index in relation to extracellular vesicle-linked microRNAs in human follicular fluid.

ABSTRACT:

Objective

To study whether increased body mass index is associated with altered expression of extracellular vesicle microRNAs (EV-linked miRNAs) in human follicular fluid.

Design

Cross-sectional study.

Setting

Tertiary-care university-affiliated center.

Patient(s)

One hundred thirty-three women undergoing in vitro fertilization (IVF) were recruited from January 2014 to August 2016.

Interventions(s)

None.

Main outcome measure(s)

EV-linked miRNAs were isolated from follicular fluid and their expression profiles were measured with the use of the Taqman Open Array Human miRNA panel. EV-linked miRNAs were globally normalized and inverse-normal transformed. Associations between body mass index (BMI) and EV-linked miRNA outcomes were analyzed by means of

SUBMITTER: Martinez RM 

PROVIDER: S-EPMC6663626 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature