Data-Driven Identification of Hydrogen Sulfide Scavengers.

ABSTRACT: Hydrogen sulfide (H₂ S) is an important signaling molecule whose up- and down-regulation have specific biological consequences. Although significant advances in H₂ S up-regulation, by the development of H₂ S donors, have been achieved in recent years, precise H₂ S down-regulation is still challenging. The lack of potent/specific inhibitors for H₂ S-producing enzymes contributes to this problem. We expect the development of H₂ S scavengers is an alternative approach to address this problem. Since chemical sensors and scavengers of H₂ S share the same criteria, we constructed a H₂ S sensor database, which summarizes key parameters of reported sensors. Data-driven analysis led to the selection of 30 potent

SUBMITTER: Yang CT 

PROVIDER: S-EPMC6663634 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature