Effects of cannabinoid administration for pain: A meta-analysis and meta-regression.

ABSTRACT: Chronic pain states have resulted in an overreliance on opioid pain relievers, which can carry significant risks when used long term. As such, alternative pain treatments are increasingly desired. Although emerging research suggests that cannabinoids have therapeutic potential regarding pain, results from studies across pain populations have been inconsistent. To provide meta-analytic clarification regarding cannabis's impact on subjective pain, we identified studies that assessed drug-induced pain modulations under cannabinoid and corresponding placebo conditions. A literature search yielded 25 peer-reviewed records that underwent data extraction. Baseline and end-point data were used to compute standardized effect size estimates (Cohen's d) across cannabinoid administrations (k = 39) and

SUBMITTER: Yanes JA 

PROVIDER: S-EPMC6663642 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature