Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder.

ABSTRACT: BACKGROUND:Individuals with bipolar disorder (BD) show aberrant brain activation patterns during reward and loss anticipation. We examined for the first time longitudinal changes in brain activation during win and loss anticipation to identify trait markers of aberrant anticipatory processing in BD. METHODS:Thirty-four euthymic and depressed individuals with BD-I and 17 healthy controls (HC) were scanned using functional magnetic resonance imaging twice 6 months apart during a reward task. RESULTS:HC, but not individuals with BD, showed longitudinal reductions in the right lateral occipital cortex (RLOC) activation during processing of cues predicting possible money loss (p-corrected <0.05). This result was not affected by psychotropic medication, mood state or the changes in depression/ma

SUBMITTER: Manelis A 

PROVIDER: S-EPMC6663653 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature