Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy.

ABSTRACT: Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood-brain barrier (BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers. Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and glioma-targeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain

SUBMITTER: Gao C 

PROVIDER: S-EPMC6663921 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature