Identification of Potential Virulence Factors in the Model Strain Acinetobacter baumannii A118.

ABSTRACT: Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is naturally competent and unlike most clinical strains, is susceptible to a variety of different antibiotics including those usually used for selection in genetic manipulations. These characteristics make strain A118 a convenient model for genetic studies of A. baumannii. To identify potential virulence factors, its complete genome was analyzed and compared to other A. baumannii genomes. A. baumannii A118 includes gene clusters coding for the acinetobactin and baumannoferrin iron acquisition systems. Iron-regulated expression of the BauA outer membrane receptor for ferric-acinetobactin complexes was confirmed as well as the utilization of acinetobactin. A. baumannii A1

SUBMITTER: Ramirez MS 

PROVIDER: S-EPMC6663985 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature