Investigation of serum proteome homeostasis during radiation therapy by a quantitative proteomics approach.

ABSTRACT: The purpose of the present study is to analyze the serum proteome of patients receiving Radiation Therapy (RT) at different stages of their treatment to discovery candidate biomarkers of the radiation-induced skin lesions and the molecular pathways underlying the radiation signatures. Six stages of RT treatment were monitored from patients treated because of brain cancer: before starting the treatment, during the treatment (four time points), and at 4 weeks from the last RT dose. Serum samples were analyzed by a proteomics approach based on the Data Independent Acquisition (DIA) mass spectrometry (MS). RT induced clear changes in the expression levels of 36 serum proteins. Among these, 25 proteins were down- or up-regulated significantly before the emergence of skin lesions. Some of these

SUBMITTER: Ouerhani A 

PROVIDER: S-EPMC6663990 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature