E6/E7 and E6^* From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes.

ABSTRACT: Keratinocyte infection with high-risk human papillomavirus genotypes has been linked to cancer development. In cervix, the alpha HPV16 and HPV18 have been reported as the mayor causative agents of cervical cancer. Oncogenic progression and chronic inflammation are closely related processes, with IL-6 as one of the main pro-inflammatory cytokines involved. However, there are limited studies about the regulation of IL-6 by low and high risk HPVs and the HPV proteins implicated in this modulation. In this work, we report the overexpression of IL-6 in HPV infected cervical cancer derived cell lines (HeLa and SiHa) compared to non-tumorigenic keratinocytes (HaCaT), and in Cervical Intraepithelial Neoplasia grade 1 HPV16 and HPV18 positive cervical samples compared to HPV negative samples withou

SUBMITTER: Artaza-Irigaray C 

PROVIDER: S-EPMC6664019 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature