Chronic Ly49H Receptor Engagement in vivo Decreases NK Cell Response to Stimulation Through ITAM-Dependent and Independent Pathways Both in vitro and in vivo.

ABSTRACT: Natural killer (NK) cells play an important role in the innate immune response. The summation of activation and inhibitory signals delivered through cell surface membrane receptors determines NK cell function. However, the continuous engagement of an activating receptor on NK cells appears to render the cells hyporesponsive to stimulation through other unrelated activating receptors. The mechanism by which this takes place remains unclear. Herein we demonstrate that continuous in vivo engagement of the Ly49H receptor with its ligand, m157, results in Ly49H⁺ NK cells that are hyporesponsive to further stimulation by other ITAM-dependent and independent receptors, while Ly49H^- NK cells remain unaffected. The hyporesponsiveness of the NK cell correlates with the d

SUBMITTER: Key PN 

PROVIDER: S-EPMC6664057 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature