Composition of the Intestinal Microbiota Determines the Outcome of Virus-Triggered Colitis in Mice.

ABSTRACT: The intestinal microbiota is a complex ecosystem implicated in host health and disease. Inflammatory bowel disease (IBD) is a multifactorial chronic disorder of the gastrointestinal mucosa. Even though the exact mechanisms are still unknown, the intestinal microbiota is crucial in IBD development. We previously showed that murine norovirus (MNV) induces colitis in the Il10-deficient (Il10 ^-/-) mouse model of IBD in a microbiota-dependent manner. Thus, in this study we analyzed whether distinct minimal bacterial consortia influence the outcome of MNV-triggered colitis in Il10 ^-/- mice. Gnotobiotic Il10 ^-/- mice associated with Oligo-Mouse-Microbiota 12 (OMM¹²) or Altered Schaedler Flora (ASF) developed little to no infl

SUBMITTER: Bolsega S 

PROVIDER: S-EPMC6664081 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature