Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect.

ABSTRACT: Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and potentials, but little attention has been paid to liposomal membrane rigidity. Herein, we sought to demonstrate the effects of cholesterol-tuned liposomal membrane rigidity on tumor penetration and anti-tumor effects. In this study, liposomes composed of hydrogenated soybean phospholipids (HSPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG₂₀₀₀) and different concentrations of cholesterol were prepared. It was revealed that liposomal membrane rigidity decreased with the addi

SUBMITTER: Wu H 

PROVIDER: S-EPMC6664103 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature