Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2-15-HETE lysophospholipids.

ABSTRACT: Recently, oxidized phospholipid species have emerged as important signaling lipids in activated immune cells and platelets. The canonical pathway for the synthesis of oxidized phospholipids is through the release of arachidonic acid by cytosolic phospholipase A₂α (cPLA₂α) followed by its enzymatic oxidation, activation of the carboxylate anion by acyl-CoA synthetase(s), and re-esterification to the sn-2 position by sn-2 acyltransferase activity (i.e. the Lands cycle). However, recent studies have demonstrated the unanticipated significance of sn-1 hydrolysis of arachidonoyl-containing choline and ethanolamine glycerophospholipids by other phospholipases to generate the corresponding 2-arachidonoyl-lysolipids. Herein, we identified a pathway

SUBMITTER: Liu GY 

PROVIDER: S-EPMC6664186 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature