Dopamine D2/D3 receptor abnormalities after traumatic brain injury and their relationship to post-traumatic depression.

ABSTRACT:

Objective

To investigate dopamine D2/D3 receptor availability following traumatic brain injury (TBI) and their relationship to the presence of DSM-IV Major Depressive Disorder (MDD) and patterns of axonal injury.

Methods

Twelve moderate-severe TBI patients and 26 controls were imaged using [¹¹C]PHNO positron emission tomography (PET) and structural magnetic resonance imaging (MRI). TBI patients and a second group of 32 controls also underwent diffusion tensor imaging (DTI) and neuropsychological assessment. Patients included six with post-injury MDD (TBI-MDD) and six without (TBI-NON). Non-displaceable binding potential (BP_ND) [¹¹C]PHNO values were used to index D2/D3 receptor availability, and were calculated using a reference region procedu

SUBMITTER: Jolly AE 

PROVIDER: S-EPMC6664227 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature