YRNAs overexpression and potential implications in allergy.

ABSTRACT:

Background

Small non-coding RNAs (snRNAs) develop important functions related to epigenetic regulation. YRNAs are snRNAs involved in the initiation of DNA replication and RNA stability that regulate gene expression. They have been related to autoimmune, cancer and inflammatory diseases but never before to allergy. In this work we described for the first time in allergic patients the differential expression profile of YRNAs, their regulatory mechanisms and their potential as new diagnostic and therapeutic targets.

Methods

From a previous whole RNAseq study in B cells of allergic patients, differential expression profiles of coding and non-coding transcripts were obtained. To select the most differentially expressed non coding transcripts, fold change and p-values were analyze

SUBMITTER: Isidoro-Garcia M 

PROVIDER: S-EPMC6664241 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature