Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis.

ABSTRACT:

Importance

The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown.

Objective

To assess whether intensive BP control would achieve fewer recurrent strokes vs standard BP control.

Design, setting, and participants

Randomized clinical trial (RCT) of standard vs intensive BP control in an intent-to-treat population of patients who had a history of stroke. Patients were enrolled between October 20, 2010, and December 7, 2016. For an updated meta-analysis, PubMed and the Cochrane Central Library database we

SUBMITTER: Kitagawa K 

PROVIDER: S-EPMC6664380 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature