Vitamin D receptor expression in invasive breast tumors and breast cancer survival.

ABSTRACT:

Background

Vitamin D has been suggested to prevent and improve the prognosis of several cancers, including breast cancer. We have previously shown a U-shaped association between pre-diagnostic serum levels of vitamin D and risk of breast cancer-related death, with poor survival in patients with the lowest and the highest levels respectively, as compared to the intermediate group. Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis.

Methods

VDR expression was evaluated in a tissue microarray of 718 invasive breast tumors. Covariation between VDR expression and established prognostic factors for breast cancer was ana

SUBMITTER: Huss L 

PROVIDER: S-EPMC6664551 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature