Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling.

ABSTRACT:

Background

Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosis. TGF-beta-induced myofibroblast differentiation characterized by expression of smooth muscle alpha-actin and extracellular matrix proteins is a key process in pathogenesis of fibrotic disease. Tannic acid is a natural polyphenol with diverse applications. In this study, we investigated the effect of tannic acid on myofibroblast differentiation and pulmonary fibrosis in cultured cells and in bleomycin model of the disease.

Methods

Primary cultured human lung fibroblasts (HLF) were used. The relative levels of proteins were determined by Western blotting. HLF

SUBMITTER: Reed EB 

PROVIDER: S-EPMC6664561 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature