Long noncoding RNA CCDC144NL-AS1 knockdown induces naive-like state conversion of human pluripotent stem cells.

ABSTRACT:

Background

Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription factors, small molecular inhibitors, and growth factors. Long noncoding RNAs (lncRNAs) have been identified to be crucial in diverse biological processes, including pluripotency regulatory circuit of mouse pluripotent stem cells (PSCs), but few are involved in human PSCs' regulation of pluripotency and naïve pluripotency derivation. This study initially planned to discover more lncRNAs possibly playing significant roles in the regulation of human PSCs' pluripotency, but accidently identified a lncRNA whose knockdown in human PSCs induced naïve-like pluripotency conve

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6664583 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature