Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer.

ABSTRACT:

Background

miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 for prognosis of gastric cancer were not researched.

Methods

We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer.

Results

The expression of miRNA 106b, miRNA 93 and miRNA 25 in plasma were positively correlated with their expression in tumor tissues. Via PCA analysis, it was found that miRNA 106b~25 expression in plasma and tumor, T, N and TNM stage were correlated with each other. Via

SUBMITTER: Li F 

PROVIDER: S-EPMC6664745 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature