Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection.

ABSTRACT:

Background

The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain largely unknown.

Methods

We have investigated the impact of T. gondii infection on the overall metabolism of mouse cerebral cortex. Mass-spectrometry-based metabolomics and multivariate statistical analysis were employed to discover metabolomic signatures that discriminate between cerebral cortex of T. gondii-infected and uninfected control mice.

Results

Our results identified 73, 67 and 276 differentially abundant metabolites, which were involved in 25, 37 and 64 pathways at 7, 14 and 21 days p

SUBMITTER: Ma J 

PROVIDER: S-EPMC6664753 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature