Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy.

ABSTRACT:

Background

Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8 months. Unlike cutaneous melanoma, mucosal melanoma is a rare melanoma subtype among Caucasian patients but its incidence remains as high as 22.6% among Chinese patients. Screening specific genetic variations is the guideline to select targeted drugs for the treatment of advanced melanoma, whereas the genetic variation spectrum and potential therapeutic targets for mucosal melanoma are largely unclear. It is urgent to identify promising genetic variants for mucosal melanoma so as to develop effective targeted therapies for this disease.

Methods

Tumor samples from 213 Chinese mucosal melanoma patients were involved

SUBMITTER: Xu L 

PROVIDER: S-EPMC6664769 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature