From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish.

ABSTRACT: In the vertebrate olfactory system, odor information is represented as a topographic map in the olfactory bulb (OB). However, it remains unknown how this odor map is transferred from the OB to higher olfactory centers. Using genetic labeling techniques in zebrafish, we found that the OB output neurons, mitral cells (MCs), are heterogeneous with respect to transgene expression profiles and spatial distributions. Tracing MC axons at single-cell resolution revealed that (1) individual MCs send axons to multiple target regions in the forebrain; (2) MCs innervating the same glomerulus do not necessarily display the same axon trajectory; (3) MCs innervating distinct glomerular clusters tend to project axons to different, but partly overlapping, target regions; (4) MCs innervating the medial glom

SUBMITTER: Miyasaka N 

PROVIDER: S-EPMC6665349 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature