Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.

ABSTRACT: To investigate the biological processes that are altered in obese subjects, we generated cell-specific integrated networks (INs) by merging genome-scale metabolic, transcriptional regulatory and protein-protein interaction networks. We performed genome-wide transcriptomics analysis to determine the global gene expression changes in the liver and three adipose tissues from obese subjects undergoing bariatric surgery and integrated these data into the cell-specific INs. We found dysregulations in mannose metabolism in obese subjects and validated our predictions by detecting mannose levels in the plasma of the lean and obese subjects. We observed significant correlations between plasma mannose levels, BMI, and insulin resistance (IR). We also measured plasma mannose levels of the subjects in

SUBMITTER: Lee S 

PROVIDER: S-EPMC6666317 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature