Calibration with or without phantom for fracture risk prediction in cancer patients with femoral bone metastases using CT-based finite element models.

ABSTRACT: The objective of this study was to develop a new calibration method that enables calibration of Hounsfield units (HU) to bone mineral densities (BMD) without the use of a calibration phantom for fracture risk prediction of femurs with metastases using CT-based finite element (FE) models. Fifty-seven advanced cancer patients (67 femurs with bone metastases) were CT scanned atop a separate calibration phantom using a standardized protocol. Non-linear isotropic FE models were constructed based on the phantom calibration and on two phantomless calibration methods: the "air-fat-muscle" and "non-patient-specific" calibration. For air-fat-muscle calibration, peaks for air, fat and muscle tissue were extracted from a histogram of the HU in a standardized region of interest including the patient's

SUBMITTER: Eggermont F 

PROVIDER: S-EPMC6667162 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature