Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.

ABSTRACT: IL-22 has opposing effects in different tissues, from pro-inflammatory (skin, joints) to protective (liver, intestine) but little is known about its effects on neuroinflammation. We examined the effect of IL-22 on retinal tissue by using the model of experimental autoimmune uveitis (EAU) in IL-22^-/- mice, as well as by intraocular injections of recombinant IL-22 or anti-IL-22 antibodies in wild type animals. During EAU, IL-22 was produced in the eye by CD4⁺ eye-infiltrating T cells. EAU-challenged IL-22^-/- mice, as well as WT mice treated systemically or intraocularly with anti-IL-22 antibodies during the expression phase of disease, developed exacerbated retinal damage. Furthermore, IL-22^-/- mice were more susceptible than WT controls to glutama

SUBMITTER: Mattapallil MJ 

PROVIDER: S-EPMC6667188 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature