Antiarrhythmic and proarrhythmic effects of subcutaneous nerve stimulation in ambulatory dogs.

ABSTRACT:

Background

High output subcutaneous nerve stimulation (ScNS) remodels the stellate ganglia and suppresses cardiac arrhythmia.

Objective

The purpose of this study was to test the hypothesis that long duration low output ScNS causes cardiac nerve sprouting and increases plasma norepinephrine concentration and the duration of paroxysmal atrial tachycardia (PAT) in ambulatory dogs.

Methods

We prospectively randomized 22 dogs (11 males and 11 females) into 5 different output groups for 2 months of ScNS: 0 mA (sham) (n = 6), 0.25 mA (n = 4), 1.5 mA (n = 4), 2.5 mA (n = 4), and 3.5 mA (n = 4).

Results

As compared with baseline, the changes in the durations of PAT episodes per 48 hours were significantly different among different groups (sham, -5.0 ± 9.5 seconds; 0.25

SUBMITTER: Wan J 

PROVIDER: S-EPMC6667287 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature